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Usage

Uses

Used in Pharmaceutical Research and Drug Development:
6-Fluoro-1H-indazol-3-ol is used as a building block or intermediate in the synthesis of other organic molecules for pharmaceutical applications. Its unique chemical structure may contribute to the development of new drugs with potential therapeutic effects.
Used in Chemical Synthesis:
6-Fluoro-1H-indazol-3-ol is utilized as a key intermediate in the synthesis of various organic compounds, particularly those with potential applications in the pharmaceutical industry. Its specific role in these syntheses is to provide a structural foundation that can be further modified to achieve desired properties in the final product.
In the field of Chemistry and Pharmacology:
6-Fluoro-1H-indazol-3-ol is used for further study and determination of its specific uses and properties. Its potential applications and effects in chemistry and pharmacology are areas of ongoing research, with the aim of uncovering its full potential in creating new therapeutic agents or chemical processes.

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 446-32-2 4-fluoroanthranilic acid 

Downstream Products

• 934703-82-9 6-fluoro-1,2-bis(4-phenylpiperazine-1-carbonyl)-1,2-dihydroindazol-3-one 
• 934703-81-8 6-fluoro-1-(4-phenylpiperazine-1-carbonyl)-1H-indazol-3-yl 4-phenylpiperazine-1-carboxylate 

Relevant academic research and scientific papers

Discovery of isatin and 1H-indazol-3-ol derivatives as D-amino acid oxidase (DAAO) inhibitors

D-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia as its inhibition increases brain D-serine level and thus contributes to NMDA receptor activation. Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. A pharmacophore and structure-activity relationship analysis of isatins and reported DAAO inhibitors led us to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified. The series was further characterized by pKa and isothermal titration calorimetry measurements. Representative compounds exhibited beneficial properties in in vitro metabolic stability and PAMPA assays. 6-fluoro-1H-indazol-3-ol (37) significantly increased plasma D-serine level in an in vivo study on mice. These results show that the 1H-indazol-3-ol series represents a novel class of DAAO inhibitors with the potential to develop drug candidates.

NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

The present invention encompasses compounds of Formula (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also

INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES

The invention relates to indazole derivatives of general formula (I) or (II), with the meanings as given in the description, the pharmaceutically-acceptable salts and use thereof as medicaments.

Indazole derivatives as inhibitors of hormone sensitive lipase

The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.