86234-45-9

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 161110-00-5 N⁴-benzoyl-3'-deoxyribicytidine 
• 532-20-7 α-D-xylofuranose 
• 129666-74-6 5’-O-(1,1-bis(4-methoxyphenyl)-1-phenylmethyl)-2’-O-tert-butyldimethylsilylcytidine 
• 86314-30-9 Imidazole-1-carbothioic acid O-[(2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester 
• 54925-66-5 2',5'-bis-O-(tert-butyldimethylsilyl)uridine 
• 19312-45-9 2',5'-di-O-acetyl-3'-deoxyuridine 
• 58-96-8 uridine 
• 161109-93-9 3'-O-phenoxythiocarbonyl-2'-O-thexyldimethylsilyl-5'-O-trityluridine 
• 161109-82-6 2'-O-thexyldimethylsilyl-5'-O-trityluridine 
• 161110-03-8 3'-O-phenoxythiocarbonyl-2',5'-di-O-thexyldimethylsilyluridine 
• 161110-04-9 1-[2,5-O-bis(tert-butyldimethylsilyl)-3-O-phenylthiocarbonyl-β-D-pentofuranosyl]-uracyl 
• 161109-90-6 1-{(2R,3R,4R,5R)-3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione 
• 161109-94-0 N⁴,2'-di-N,O-acetyl-3'-deoxy-5'-O-(4-methylbenzoyl)-cytidine 

Downstream Products

• 189026-00-4 Acetic acid (2R,3R,5S)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-5-hydroxymethyl-tetrahydro-furan-3-yl ester 
• 157327-96-3 4-N-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 2-cyanoethyl N,N-diisopropylphosphoramidite 

Relevant academic research and scientific papers

Conformational rigidity introduced by 2′,5′-phosphodiester links in DNA

Conformational properties of 2′,5′-linked 3′-deoxyribonucleotides have been compared with their natural isomer using CD spectroscopy. It is inferred from the salt induced titration curves that the 2′,5′-linked3′deoxyribonucleotides have rigid phosphodiest

Nucleosides. LVI. Synthesis and chemical modifications of 3'-deoxy- pyrimidine nucleosides

3'-Deoxyuridine(1) and 3'-deoxycytidine(2) were prepared with improved yields by two different methods applying either the Barton procedure to appropriate 2',5'-di-O-protected pyrimidine nucleosides or by choosing the direct glycosylation of the pyrimidine bases with 1,2-di-O-acetyl-5-O- toluoyl-3-deoxy-D-erythro-pentofuranose via the silylation approach. Suitable protecting groups for the sugar moiety have been found in the trityl, tert- butyldimethylsilyl and the thexyl groups which are inert in the radical deoxygenation process. The newly synthesised compounds were characterized by elemental analyses and UV and 1H-NMR spectra.

CONVERSION OF RIBONUCLEOSIDES TO PROTECTED 3'-DEOXYNUCLEOSIDES

A procedure is presented for the conversion of ribonucleosides to 3'-deoxyribonucleosides and their protected derivatives.