129666-74-6

Upstream product

• 16640-05-4 1-(β-D-arabinofuranosyl)-N⁴-benzoylcytosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 87418-76-6 N-(1-{(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
• 81246-76-6 4-N-benzoyl-1-(5-O-dimethoxytrityl-β-D-ribofuranosyl)cytosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 160056-42-8 C₉H₁₃N₃O₅SiC₆H₁₄PO₃HC(C₆H₅)3C₂H₃O₂C₇H₄C₆H₄ 
• 136044-35-4 N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)cytidine 3'-O-(2-cyanoethyl N,N-diethylphosphoramidite) 
• 118380-84-0 N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)cytidine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) 
• 137760-81-7 C₄₃H₅₀N₃O₁₀PSi*C₆H₁₅N 
• 127578-31-8 5'-O-DMTr-2'-O-TBDMS-N-Bz-cytidine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt 
• 86314-30-9 Imidazole-1-carbothioic acid O-[(2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester 
• 81279-41-6 5'-dimethoxytrityl 2'-tert-butyldimethyl silyl N-benzoyl cytidine 3'-p-chlorophenyl β-cyanoethyl phosphotriester 
• 118362-05-3 C₄₆H₅₈N₅O₁₄PSi*H₃N 
• 86234-45-9 N⁴-benzoyl-5'-O-dimethoxytrityl-3'-deoxyribicytidine 
• 86234-38-0 N-{1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 129395-59-1 C₄₈H₅₈N₅O₈PSSi 
• 131289-16-2 N¹-benzoyl-2'-O-tert-butyldimethylsilyl-3'-O-succinyl-5'-O-dimethoxytrityl-cytidine 
• 944137-38-6 N¹-benzoyl-3'-O-tert-butyldimethylsilyl-2'-O-succinyl-5'-O-dimethoxytrityl-cytidine 
• 944137-51-3 C₇H₇O₃S^(1-)*C₃₂H₄₄N₅O₉Si⁽¹⁺⁾ 

Relevant academic research and scientific papers

Practical silyl protection of ribonucleosides

Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows f

CHEMICAL SYNTHESIS OF DIMER RIBONUCLEOTIDES CONTAINING INTERNUCLEOTIDIC PHOSPHORODITHIOATE LINKAGES

Ribonucleosides, chlorobis(amino)phosphines and thiols react via phosphorothioamidites to form phosphorothioites.Oxidation with sulphur gives ribonucleoside phosphorodithioate triesters which after deprotection yields the phosphorodithioate ribonucleoside

The preparation of protected arabinonucleosides

A general procedure is described for the preparation of protected arabinonucleosides.Protection at the 5'-position involves triphenylmethyl groups (DMT and MMT) while the tert-butyldimethylsilyl (TBDMS) group is used to protect the 2'- or 3'-positions.The

Modified phosphotriester method for chemical synthesis of ribooligonucleotides. Part I. Synthesis of riboundecaadenylate and two fragments constituting the sequence of R-17 translation control signal

A modified phosphotriester method has been succesfully applied for the chemical synthesis of ribooligonucleotides.The starting material is a fully protected ribomononucleoside containing a 3'-phosphotriester group 5.The coupling reaction is performed usin

New catalists and procedures for the dimethoxytritylation and selective silylation of ribonucleosides

Procedures have been developed for the selective formation of (a) 2',5'-silylated ribonucleosides and (b) 3',5'-silylated ribonucleosides.These procedures also permit the selective silylation at either the 2'- or 3'-position of dimethoxytritylated ribonuc

HIGH YIELD SELECTIVE 3'-SILYLATION OF RIBONUCLEOSIDES

Prucedures have been developed which permit the highly selective silylation of the 3'-hydroxyl of ribonucleosides to produce 3',5'-diprotected derivatives in high yields.

NITRATE ION AS CATALYST FOR SELECTIVE SILYLATIONS OF NUCLEOSIDES

Nitrate ion has been found to have a remarkable effect on the selectivity of silylation of ribonucleosides using the t-butyldimethylsilyl group.