86239-22-7

Upstream product

• 80224-53-9 3-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-5-phenyl-3H-thiophen-2-one 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

Benzylidene-Thiolactone Rearrangement: Synthesis and Rearrangement of 5-Substituted 3-Benzylidene-4-thiolen-2-ones

Condensation of 5-substituted 4-thiolen-2-ones (1) with aromatic aldehydes (2) in anhydrous ethanolic HCl generates the 3-benzylidene derivatives 3.These can be rearranged in base (benzylidene-thiolactone rearrangement) to 2,5-disubstituted thiophene-3-carboxylic acids (4, 5, or 6).