862422-29-5

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 10019-95-1 N-tosylpyrrolidinone 
• 862422-06-8 3,3-dibenzyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-one 
• 862422-13-7 3,3-dibenzyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ol 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 1252671-12-7 (3aR,9aR)-3a-benzyl-1-tosyl-2,3,3a,4,9,9a-hexahydro-1H-benzo[f]indole 
• 862422-21-7 N-allyl-N-(3,3-dibenzyl-pent-4-enyl)-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Diastereo- and enantioselective copper-catalyzed intramolecular carboamination of alkenes for the synthesis of hexahydro-1 H-benz[f]indoles

A new method for the enantioselective synthesis of hexahydro-1H-benz[f] indoles is described. This copper-catalyzed enantioselective intramolecular alkene carboamination process can install vicinal tertiary and quaternary carbon stereocenters with high levels of diastereo- and enantioselectivity. The C-C bond-forming component of the reaction constitutes a C-H functionalization and no electronic activation of the aryl ring that undergoes addition is required. A known 5-HT1A receptor antagonist was synthesized efficiently using this method.

Synthesis of a novel series of 4,4-disubstituted 2,3,4,7-tetrahydroazepines

A general, simple and straightforward strategy for the synthesis of a novel series of 4,4-disubstituted 2,3,4,7-tetrahydroazepines is described. This route involves a one-pot Wittig olefination/N-allylation process on a five-membered hemi-aminal followed by a final ring closing metathesis reaction.