862464-32-2

Upstream product

• 1443322-44-8 methyl 3-[(2S)-2-hydroxy-4-phenylbutyl]but-3-enoate 
• 104-53-0 3-phenyl-propionaldehyde 
• 157732-87-1 (4S)-2,2-dimethyl-4-(2-phenylethyl)-1,3-dioxolane 
• 118629-73-5 (S)-2-hydroxy-4-phenylbutyl 4-methylbenzenesulfonate 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 125103-96-0 (S)-5-phenyl-3-hydroxypentanenitrile 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 587-63-3 7,8-dihydrokawain 
• 182950-96-5 (6S)-6-(2-phenylethyl)dihydropyran-2,4⁽³⁾-dione 

Relevant academic research and scientific papers

Enantioselective synthesis of (+)-(S)-7,8-dihydrokavain and (4R,6R)-4-hydroxy-6-(2-phenylethyl)tetrahydro-2H-pyran-2-one, lactone analog of compactin and mevinolin

A simple and efficient asymmetric synthesis was performed of (+)-(S)-7,8-dihydrokanian and (4R,6R)-4-hydroxy-6-(2-phenylethyl)tetrahydro-2H- pyran-2-one involving Keck allylation in the key stage of building up the carbon scaffold of the target molecules.

A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(