182950-96-5

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 1443322-44-8 methyl 3-[(2S)-2-hydroxy-4-phenylbutyl]but-3-enoate 
• 100-39-0 benzyl bromide 
• 157732-87-1 (4S)-2,2-dimethyl-4-(2-phenylethyl)-1,3-dioxolane 
• 152203-65-1 (4S)-2,2-dimethyl-4-styryl-1,3-dioxolane 
• 118629-73-5 (S)-2-hydroxy-4-phenylbutyl 4-methylbenzenesulfonate 
• 125103-96-0 (S)-5-phenyl-3-hydroxypentanenitrile 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 118133-69-0 (3S) methyl 3-hydroxy-5-phenylpentanoate 
• 129880-16-6 3-hydroxy-5-phenyl-pentanoic acid methyl ester 
• 30414-58-5 methyl 3-oxo-5-phenylpentanoate 
• 918148-53-5 (S)-3-Acetoxy-5-phenyl-pentanoic acid methyl ester 
• 862464-32-2 methyl (5S)-5-hydroxy-3-oxo-7-phenylheptanoate 

Downstream Products

• 587-63-3 7,8-dihydrokawain 

Relevant academic research and scientific papers

Enantioselective synthesis of (+)-(S)-7,8-dihydrokavain and (4R,6R)-4-hydroxy-6-(2-phenylethyl)tetrahydro-2H-pyran-2-one, lactone analog of compactin and mevinolin

A simple and efficient asymmetric synthesis was performed of (+)-(S)-7,8-dihydrokanian and (4R,6R)-4-hydroxy-6-(2-phenylethyl)tetrahydro-2H- pyran-2-one involving Keck allylation in the key stage of building up the carbon scaffold of the target molecules.

Chemoenzymatic synthesis of enantiomerically enriched kavalactones

Lipase-mediated kinetic resolution of methyl-3-hydroxy-5-phenylpentanoate and (6E)-ethyl 5-hydroxy-3-oxo-7-phenylhept-6-enoate is described in high enantiomeric excess and good yields. The effect of different lipases in different solvents has been screened using different acylating agents. This protocol has been extended for the preparation of enantiomerically pure biologically important kavalactones.

A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(

Synthetic derivatives

This invention features a 5,6-dihydro-2-pyrone compound of formula (I), wherein R1 is H, OH, or C2?C5 alkoxyl; and R2 is 2-phenyl ethyl, 2-phenyl ethenyl, 2-heteroaryl ethyl, or 2-heteroaryl ethenyl; in which th

Enantioselective synthesis of (+)- and (-)-dihydrokawain

The first asymmetric synthesis of (+)- and (-)-dihydrokawain, an α-dihydropyrone isolated from the roots of Piper mythisticum, is reported. (+)-Dihydrokawain is the natural product and is of S-configuration.