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CAS

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862468-60-8

6-amino-1-benzyl-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 862468-60-8 Structure

  • Basic information

    1. Product Name: 6-amino-1-benzyl-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione
    2. Synonyms: 6-amino-1-benzyl-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione
    3. CAS NO:862468-60-8
    4. Molecular Formula:
    5. Molecular Weight: 288.306
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 862468-60-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-amino-1-benzyl-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-amino-1-benzyl-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione(862468-60-8)
    11. EPA Substance Registry System: 6-amino-1-benzyl-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione(862468-60-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 862468-60-8(Hazardous Substances Data)

862468-60-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 862468-60-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,2,4,6 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 862468-60:
(8*8)+(7*6)+(6*2)+(5*4)+(4*6)+(3*8)+(2*6)+(1*0)=198
198 % 10 = 8
So 862468-60-8 is a valid CAS Registry Number.

862468-60-8Relevant articles and documents

New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists

Baraldi, Pier Giovanni,Preti, Delia,Tabrizi, Mojgan Aghazadeh,Fruttarolo, Francesca,Romagnoli, Romeo,Zaid, Naser Abdel,Moorman, Allan R.,Merighi, Stefania,Varani, Katia,Borea, Pier Andrea

, p. 4697 - 4701 (2005)

Compounds presenting an additional fused ring on the xanthine nucleus have been reported to exhibit antagonistic activity with various levels of affinity and selectivity toward the four adenosine receptors subtypes A1, A2A, A2B

Novel adenosine A3 receptor modulators

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Page/Page column 17, (2008/06/13)

A class of novel antagonists for the adenosine A3 receptor are disclosed. These compounds are useful as therapeutic agents for a number of diseases and medical conditions that are mediated by the A3 receptor. The compounds of this in

A1 adenosine receptor antagonists as ligands for positron emission tomography (PET) and single-photon emission tomography (SPET).

Holschbach,Fein,Krummeich,Lewis,Wutz,Schwabe,Unterlugauer,Olsson

, p. 555 - 563 (2007/10/03)

The high affinity of 8-cyclopentyl-1,3-dipropylxanthine (CPX) for the A1 adenosine receptor (A1AR) provides a good lead for developing radioligands suitable for positron emission tomography (PET) and single-photon emission tomography (SPET). This study tested the hypothesis that the kinds of chemical modifications made in the synthesis of CPX analogues containing carbon-11, fluorine-18, or radioiodine will not alter affinity for the A1AR. This report describes the synthesis and radioligand binding assays of unlabeled CPX analogues having methyl, 2-methoxyethyl, 2-fluoropropyl, or 3-fluoropropyl substituents, respectively, at either N-1 (13a-d) or N-3 (8a-d) or an (E)-3-iodoprop-2-en-1-yl substituent at N-3 (8f). Compounds 8d,f and 13b,d antagonized the binding of [3H]CPX to the A1AR of rat brain with affinities similar to those of CPX; compound 8c was twice as potent as CPX. Analogues 8a,b and 13a were less potent than CPX, but for each the Ki of antagonism was > or = 0.5 nM. Attempts to iodinate the 8-(4-hydroxyphenyl) analogue of CPX failed, probably because the xanthine substituent strongly deactivated the phenol toward electrophilic iodination. In summary, several of the modifications of the propyl groups of CPX needed to produce ligands for imaging by PET and SPET preserve or enhance affinity for the A1AR.

PROCESS FOR PREPARING 1,3-DIPROPYL-8-(3-OXOCYCLOPENTYL)-XANTHINE

-

, (2008/06/13)

A process for preparing 1,3-dipropyl-8-(3-oxocyclopentyl)-xanthine.

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