862479-41-2Relevant academic research and scientific papers
Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge
Kotoku, Naoyuki,Hiramatsu, Atsushi,Tsujita, Hiroaki,Hirakawa, Yoichi,Sanagawa, Mami,Aoki, Shunji,Kobayashi, Motomasa
scheme or table, p. 568 - 577 (2009/04/06)
A structure-activity relationship (SAR) study of bastadin 6 (1), a brominated tyrosine-derived metabolite from Indonesian marine sponge having a potent anti-angiogenic activity, was executed. The syntheses and their biological evaluation of the oxime-modified analogues and bromine-modified analogues revealed that both the oxime moieties and bromine atoms in bastadin 6 (1) play an important role to show the potent and selective anti-proliferative activity against human umbilical vein endothelial cells (HUVECs).
Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge
Kotoku, Naoyuki,Tsujita, Hiroaki,Hiramatsu, Atsushi,Mori, Chinatsu,Koizumi, Noriko,Kobayashi, Motomasa
, p. 7211 - 7218 (2007/10/03)
An efficient total synthesis of bastadin 6 (1), a cyclic tetramer of brominated tyrosine derivatives from the marine sponge, Ianthella basta, with selective anti-angiogenic activity, was accomplished. We developed a novel Ce(IV)-mediated oxidative couplin
