210880-82-3

Upstream product

• 210880-88-9 N-(tert-butoxycarbonyl)-3,5-dibromo-4-hydroxy-β-phenethylamine 
• 73414-58-1 2-(3,5-dibromo-4-hydroxyphenyl)ethan-1-amine hydrobromide 
• 51-67-2 tyrosamine 
• 210880-89-0 tert-butyl {2-[3,5-dibromo-4-(10-bromo-2,9-dioxo-1-oxa-3-azaspiro[5.5]undeca-7,10-dien-8-yloxy)phenyl]ethyl}carbamate 

Downstream Products

• 862479-41-2 2-benzyloxyimino-3-(3-{4-[2-benzyloxyimino-2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylaminoethyl)phenoxy]-4-hydroxyphenyl}ethylcarbamoyl)ethyl]-2,6-dibromophenoxy}-5-bromo-4-hydroxyphenyl)propionic acid 
• 1083067-28-0 (2-{3,5-dibromo-4-[3-bromo-5-(2-{3-[3,5-dibromo-4-(9-bromo-3-methoxyimino-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)phenyl]-2-methoxyiminopropionylamino}ethyl)-2-hydroxyphenoxy]phenyl}ethyl)carbamic acid tert-butyl ester 
• 1083067-29-1 (2-{3,5-dibromo-4-[3-bromo-5-(2-{3-[3,5-dibromo-4-(9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yloxy)phenyl]propionylamino}ethyl)-2-hydroxyphenoxy]phenyl}ethyl)carbamic acid tert-butyl ester 
• 1083067-30-4 [(3S,5RS)-7-(4-{(2S)-2-benzyloxycarbonylamino-2-[2-(3-bromo-5-{2,6-dibromo-4-[2-(tert-butoxycarbonylamino)ethyl]phenoxy}-4-hydroxyphenyl)ethylcarbamoyl]ethyl}-2-6-dibromophenoxy)-9-bromo-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-3-yl]carbamic acid benzyl ester 
• 1083067-31-5 C₅₅H₅₀Br₆N₄O₁₃ 
• 210880-84-5 3-[3-Bromo-5-(2,6-dibromo-4-{2-(2-{3-bromo-5-[2,6-dibromo-4-(2-tert-butoxycarbonylamino-ethyl)-phenoxy]-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid 
• 210880-85-6 3-[3-(4-{2-(2-{3-[4-(2-Amino-ethyl)-2,6-dibromo-phenoxy]-5-bromo-4-hydroxy-phenyl}-ethylcarbamoyl)-2-[(E)-hydroxyimino]-ethyl}-2,6-dibromo-phenoxy)-5-bromo-4-hydroxy-phenyl]-2-[(Z)-hydroxyimino]-propionic acid 
• 210880-83-4 (2-{3,5-Dibromo-4-[3-bromo-5-(2-{3-(3,5-dibromo-4-{9-bromo-3-[(Z)-hydroxyimino]-2,8-dioxo-1-oxa-spiro[4.5]deca-6,9-dien-7-yloxy}-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-ethyl)-2-hydroxy-phenoxy]-phenyl}-ethyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge

An efficient total synthesis of bastadin 6 (1), a cyclic tetramer of brominated tyrosine derivatives from the marine sponge, Ianthella basta, with selective anti-angiogenic activity, was accomplished. We developed a novel Ce(IV)-mediated oxidative couplin

Total synthesis of bastadins 2, 3, and 6

A chemoenzymatic strategy has been developed for the synthesis of bastadins 2, 3, and 6. The requisite dimeric dityrosine and isodityrosine building blocks were successfully prepared by oxidative C - C and C - O phenolic coupling of mono- and dihalogenated derivatives of tyrosine and tyramine using horseradish and soybean peroxidases. By carefully controlling the experimental parameters, the requisite synthons may now be prepared in synthetically useful yields without the exhaustive protection and deprotection of the sensitive functional groups.