862647-09-4

Usage

Uses

Used in Pharmaceutical Synthesis:
(2R)-2-benzhydryloxirane is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form various functional groups through ring-opening reactions, contributing to the development of new drugs.
Used in Agrochemical Production:
(2R)-2-benzhydryloxirane is used as a building block in the production of agrochemicals, enabling the creation of complex organic compounds that can be utilized in the development of pesticides and other agricultural chemicals.
Used in Polymer Synthesis:
(2R)-2-benzhydryloxirane is used as a monomer or a reactive component in the synthesis of polymers, allowing for the formation of polymers with specific properties and applications.
Used in Organic Synthesis:
(2R)-2-benzhydryloxirane is used as a versatile reagent in organic synthesis for its ability to participate in various chemical reactions, leading to the formation of a wide range of organic compounds.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
(2R)-2-benzhydryloxirane is used as a chiral auxiliary in various asymmetric synthesis reactions, aiding in the production of enantiomerically pure compounds, which are essential in the pharmaceutical and chemical industries.
Used in Material Science:
(2R)-2-benzhydryloxirane is used in the field of material science for its potential applications in creating new materials with unique properties, such as advanced polymers and composites.
It is important to handle (2R)-2-benzhydryloxirane with caution as it can be hazardous if not used properly.

Upstream product

• 15701-83-4 1,1-diphenyl-2,3-epoxy-propan 
• 117-34-0 2,2-diphenylacetic acid 
• 3469-00-9 methyl 2,2-diphenylacetate 
• 53780-27-1 1,1-diphenyl-3-bromo-propan-2-ol 
• 33609-25-5 3-bromo-1,1-diphenylpropan-2-one 
• 781-35-1 1,1-diphenylacetone 
• 3542-14-1 3,3-diphenylpropene 
• 947-91-1 Diphenylacetaldehyde 
• 4646-55-3 N,N-dimethyl-3,3-diphenylpropan-1-amine 
• 101-81-5 Diphenylmethane 
• 862647-11-8 (2S)-3,3-diphenylpropane-1,2-diol 

Downstream Products

• 862647-12-9 (2S)-1,1-diphenylpent-4-en-2-ol 
• 1332886-85-7 (2S,4R,5R)-2-benzhydryl-5-bromotetrahydro-2H-pyran-4-ol 
• 1282672-36-9 (S)-1,1-diphenylhex-5-en-2-ol 
• 869114-32-9 (3R,6S)-6-benzhydryltetrahydro-2H-pyran-3-ol 

Relevant academic research and scientific papers

METHOD OF PREPARING AZA-PYRIDONE COMPOUNDS

Disclosed herein are methods for obtaining aza-pyridone compounds, which can be useful for ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection.

AZA-PYRIDONE COMPOUNDS AND USES THEREOF

Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.

An improved asymmetric synthetic route to a novel triple uptake inhibitor antidepressant (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H- pyran-4-ol (D-142)

Triple monoamine reuptake inhibitors have been implicated in the development of a new generation of antidepressants with higher efficacy than the currently existing therapies. In this paper, we have developed an alternative efficient synthetic route for triple monoamine reuptake inhibitor D-142 in 18.5% overall yield in 11 steps starting from diphenylmethane. D-142 was developed by us recently. The key step of the present synthetic strategy is the preferential formation of a bromohydrin from olefin via a cis-bromonium intermediate, which introduced significant efficiency in the overall synthesis. Furthermore, we have developed an efficient way to recycle the optically active intermediate diol back to the desired chiral epoxide.

Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner

In our structure-activity relationship study on 3,6-disubstituted pyran derivatives, we have carried out asymmetric synthesis and biological characterization of trisubstituted (2S,4R,5R)-2-benzhydryl-5- benzylaminotetrahydropyran-4-ol and (3S,4R,6S)-6-ben

TRI-SUBSTITUED 2-BENZHYDRYL-5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES

Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti- depressants.