862653-93-8Relevant academic research and scientific papers
Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties
Zebbiche, Zineddine,Tekin, Suat,Kü?ükbay, Hasan,Yüksel, Furkan,Boumoud, Boudjemaa
, (2020/12/29)
Nine novel hydrazone derivatives (4a–i) incorporating pyridine and isatin moieties were synthesized through one-pot, four-component heterocyclic condensation reactions. The structures of all new compounds (2a–e, 3a, 3c–e, and 4a–e) were identified by sup
A microwave approach to the synthesis of certain 4-(substituted phenyl)-6-phenyl-3-cyano-2-pyridones
Marinkovic, Aleksandar,Mijin, Du?an,Mirkovic, Jelena,Maslak, Veselin,Kappe, C. Oliver
, p. 759 - 765 (2014/11/27)
A study of the synthesis of 4-(substituted phenyl)-6-phenyl-3-cyano- 2-pyridones from ethyl 2-cyano-3-(substituted phenyl) acrylates and acetophenone is presented. The 2-pyridones were obtained using conventional as well as microwave synthesis under solvent and solvent-free conditions in domestic and laboratory microwave ovens. The structure of the obtained pyridones was confirmed by m.p., FT-IR, NMR and UV data.
An efficient and facile multicomponent synthesis of 4,6-diarylpyridine derivatives under solvent-free conditions
El-Sayed, Hassan A.,Ouf, Nabil H.,Moustafa, Ahmed H.
, p. 407 - 412 (2014/02/14)
We present an efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2- dihydropyridine-3-carbonitriles (5a-j) via a four-component system of aromatic aldehydes (1), acetophenones (2), ethyl cyanoacetate (3), and ammonium acetate (4). The short reaction tim
Cascade synthesis of 2-pyridones using acrylamides and ketones
Rai, Sunil K.,Khanam, Shaziya,Khanna, Ranjana S.,Tewari, Ashish K.
, p. 44141 - 44145 (2015/02/02)
Microwave assisted non-catalytic condensation of 2-cyanoacetamide with aromatic aldehydes, and enolate mediated Michael-type addition to acrylamide followed by oxidative cyclization, produce 2-pyridones in good to excellent yield. Unsymmetrical ketones produce two regioisomeric enolates, therefore thermodynamic and kinetic products of butan-2-one and pentan-2-one have been isolated and fully characterized. This journal is
