862730-60-7

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 3396-99-4 methyl α-D-galactopyranoside 
• 100-39-0 benzyl bromide 
• 181480-80-8 6-O-tert-butyldimethylsilanyl-1-O-methyl-α-D-galactopyranoside 

Downstream Products

• 1401562-76-2 methyl 2,3,4-tri-O-benzyl-7,8-dideoxy-D-glycero-α-D-galacto-oct-7-enopyranoside 
• 1401562-79-5 methyl 2,3,4-tri-O-benzyl-7,8-dideoxy-L-glycero-α-D-galacto-oct-7-enopyranoside 
• 1401562-80-8 methyl 6-O-acetyl-2,3,4-tri-O-benzyl-7,8-dideoxy-D-glycero-α-D-galacto-oct-7-enopyranoside 
• 1401562-82-0 methyl 6-O-acetyl-2,3,4-tri-O-benzyl-α-D-erythro-D-galacto-octopyranoside 
• 1401562-84-2 methyl 6,7,8-tri-O-acetyl-2,3,4-tri-O-benzyl-α-D-erythro-D-galacto-octopyranoside 
• 1401562-98-8 C₄₀H₄₁F₃O₈ 
• 1401562-95-5 C₄₀H₄₁F₃O₈ 
• 134680-55-0 methyl 2,3,4-tri-O-benzyl-α-D-galacto-hexodialdo-1,5-pyranoside 
• 4356-80-3 methyl 2,3,4-tri-O-benzyl-α-D-galactopyranoside 

Relevant academic research and scientific papers

Chiron approach to the total synthesis of Amaryllidaceae alkaloid (+)-lycoricidine

A highly stereoselective total synthesis of Amaryllidaceae alkaloid starting from α-D-galactopyranoside has been described. The salient features of this total synthesis are Ferrier carbocyclization reaction for the synthesis of ring A and Suzuki Miyaura c

Carbohydrate based hyper-crosslinked organic polymers with -OH functional groups for CO2 separation

Recently, microporous organic polymers, especially those hyper-crosslinked from functionalized aromatic monomers, have been shown to be effective for CO2 capture and storage with considerable capacity and selectivity. Herein, a class of novel m

Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: Characterization of the reactions catalyzed by LmbR and LmbN

Lincomycin A is a potent antimicrobial agent noted for its unusual C1 methylmercapto-substituted 8-carbon sugar. Despite its long clinical history for the treatment of Gram-positive infections, the biosynthesis of the C 8-sugar, methylthiolincosamide (MTL), is poorly understood. Here, we report our studies of the two initial enzymatic steps in the MTL biosynthetic pathway leading to the identification of d-erythro-d-gluco-octose 8-phosphate as a key intermediate. Our experiments demonstrate that this intermediate is formed via a transaldol reaction catalyzed by LmbR using d-fructose 6-phosphate or d-sedoheptulose 7-phosphate as the C3 donor and d-ribose 5-phosphate as the C5 acceptor. Subsequent 1,2-isomerization catalyzed by LmbN converts the resulting 2-keto C8-sugar (octulose 8-phosphate) to octose 8-phosphate. These results provide, for the first time, in vitro evidence for the biosynthetic origin of the C8 backbone of MTL.

An approach to the synthesis of α-(1-6)-C-disaccharides by tandem Tebbe methylenation and Claisen rearrangement

Uronic acids, most efficiently synthesised from the corresponding alcohols by two step Dess-Martin and sodium chlorite mediated oxidation, may be used as coupling partners for esterification with an allo glycal as substrates for the tandem Tebbe/Claisen a