86278-61-7

Usage

InChI:InChI=1/C8H5BrN2/c9-8-7-5-10-3-1-6(7)2-4-11-8/h1-5H

Upstream product

• 67988-50-5 2,7-naphthyridinyl-1(2H)-one 
• 950746-11-9 4-[2-pyrrolidin-1-ylvinyl]nicotinonitrile 
• 5444-01-9 3-cyano-4-methylpyridine 
• 36106-34-0 4-(2-dimethylamino-vinyl)-nicotinonitrile 

Relevant academic research and scientific papers

A 2, 7-naphthyridine-based fluorescent turn-on probe for detection of biothiols in vitro and in vivo

A 2,7-naphthyridine derivative (AND-OH) was used as a fluorophore in the development of a novel fluorescent turn-on probe (AND-DNBS) by introducing a 2,4-dinitrobenzenesulfonate functionality. This fluorescent probe was successfully used for sensing glutathione (GSH) in aqueous media and showed favorable properties such as a rapid response time (45 s) and a significant Stokes shift (227 nm). The characteristics of the developed probe are better than those of another probe, namely ND-DNBS, which was also synthesized by our group and most other previously reported fluorescent probes for GSH. The AND-DNBS probe was able to detect GSH via a red emission in living A549 cells and zebrafishes. These results show that AND-DNBS has potential applications as an excellent probe for detecting GSH in various environments.

Fluorescent probe for rapidly identifying -SH compound and preparation method thereof

The invention discloses a fluorescent probe for rapidly identifying an -SH compound and a preparation method thereof. The fluorescent probe has a naphthyridine structure providing large Stokes shift,and has strong anti-interference property. At the same t

Process for Preparing 1-Halo-2,7-Naphthyridinyl Derivatives

A process for preparing 1-halo-2,7-naphthyridinyl derivatives is described (I), wherein X is Cl or Br; which process comprises the following steps: (i) reaction of a 3-cyano-4-methylpyridine derivative of formula (A): with a compound of formula (II), in the presence of an N,N-dimethylformamide diC1-6alkylacetal; to give an enamine derivative of formula (III), (ii) cyclisation of the enamine of formula (III), to obtain the compound of formula (IV), (iii) reaction of the compound of formula (IV) with a halogenating agent, to obtain a compound of formula (I).

The amination of halogeno-2,7- and 1,8-naphthyridines

The conversion of 1-halogeno-2,7-naphthyridines into the corresponding 1-amino compounds with KNH2/NH3, is shown, by the use of deuterated starting compounds, to proceed via an SN(AE)ipso substitution and not via an SN(AE)tele mechanism, even though convincing evidence for the formation of tele ?-adduct, 8-amino-1-halogeno-dihydro-2,7-naphthyridine, was obtained.Using the same methods, it is shown that the conversion of 2-bromo-1,8-naphthyridine into 2-amino-1,8-naphthyridine proceds, to the extent of 40percent via an odd SN(AE)tele pathway.