862816-15-7

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 64805-08-9 ethyl glyoxylate hydrate 
• 13422-77-0 3-(4-methoxy-phenyl)-3-oxo-propionic acid 

Downstream Products

• 92157-21-6 ethyl 2-hydroxy-4-(4-methoxyphenyl)butanoate 
• 2166-33-8 6-(4-methoxy-phenyl)-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Stereospecific Hydrogenolysis of Benzylic Alcohols over Pd/C

Hydrogenolysis of tertiary benzylic alcohols on palladium on carbon (Pd/C) generally proceeds with inversion of configuration. However, little is known about the hydrogenolysis mechanism of primary and secondary benzylic alcohols. Literature precedents su

Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water

An environmentally benign decarboxylative aldol reaction of β-ketoacids with glyoxylate and glyoxal monohydrates in water is reported. The reaction proceeds smoothly without any base and metal catalysts, affording the corresponding β-hydroxy ketones in high yields. A preliminary mechanism study of this aldol transformation suggests a stepwise process involving the nucleophilic addition of β-ketoacids to glyoxylate hydrates and glyoxal monohydrates followed by a subsequent decarboxylation reaction.

Use of thiazole derivatives and analogues in disorders caused by free fatty acids

There is provided a use of a compound of formula I, wherein X, T, Y, W, A1, A2, R1, R5 and R6 have meanings given in the description, for the manufacture of a medicament for the treatment of a disorde

NEW COMBINATION FOR USE IN THE TREATMENT OF CANCER

There is provided combination products comprising (a) a compound of formula (I): wherein X, Y, T, W, A1, A2 R1, R5 and R6 have meanings given in the description, and (b) tamoxifen or an aromatase inhi

THIAZOLIDINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND DISORDERS CAUSED BY EXCESS ADIPOSITY

There is provided a compound of formula (I) wherein X, Y, T, W, A1, A2, R1, R5 and R6 have meanings given in the description. Such compounds are potentially useful in the treatment of cancer, such as

NITROGENOUS FUSED HETEROAROMATIC RING DERIVATIVE

The invention provides a compound or its pharmaceutically-acceptable salt of formula (I): wherein A1 is a hydrogen, etc.; j and k are 0 or 1; is a double bond, etc.; is a double bond, etc.; one of W1 and W2 is E-O-W, etc., and the other is a hydrogen atom, etc.; E is a divalent group derived from a benzene ring, etc., by removing two hydrogen atoms therefrom; W is a group of formula (II-1): which has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for prevention or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.