862822-92-2Relevant academic research and scientific papers
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors
Gangjee, Aleem,Li, Wei,Lin, Lu,Zeng, Yibin,Ihnat, Michael,Warnke, Linda A.,Green, Dixy W.,Cody, Vivian,Pace, Jim,Queener, Sherry F.
experimental part, p. 7324 - 7336 (2010/03/30)
To optimize dual receptor tyrosine kinase (RTK) and dihydrofolate reductase (DHFR) inhibition, the E- and Z-isomers of 5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamines (1a and 1b) were separated by HPLC and the X-ray crystal structu
Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity
Gangjee, Aleem,Zeng, Yibin,Ihnat, Michael,Warnke, Linda A.,Green, Dixy W.,Kisliuk, Roy L.,Lin, Fu-Tyan
, p. 5475 - 5491 (2007/10/03)
Recent evidence suggests that combination therapy of cancer with receptor tyrosine kinase (RTK) inhibitors, which are usually cytostatic, with conventional chemotherapeutic agents, which are usually cytotoxic, provide an improved treatment option. We have
