862891-89-2Relevant academic research and scientific papers
Ring-selective functionalization of N,N′-diarylureas by regioselective N-alkylation and directed ortho metalation
Clayden, Jonathan,Turner, Hazel,Pickworth, Mark,Adler, Thomas
, p. 3147 - 3150 (2007/10/03)
(Chemical Equation Presented) Unsymmetrical N,N′-diarylureas may be alkylated regioselectively at the more sterically congested nitrogen atom. The resulting mono-N-alkylated ureas undergo directed metalation (ortholithiation) with sec-BuLi to yield, on el
Slow interconversion of enantiomeric conformers or atropisomers of anilide and urea derivatives of 2-substituted anilines
Adler, Thomas,Bonjoch, Josep,Clayden, Jonathan,Font-Bardia, Merce,Pickworth, Mark,Solans, Xavier,Sole, Daniel,Vallverdu, Lluis
, p. 3173 - 3183 (2007/10/03)
N-Acylated 2-substituted anilines undergo slow Ar-N bond rotation, allowing in some cases isolation of enantiomeric or diastereoisomeric atropisomers and in others the determination of the rate of Ar-N bond rotation by NMR. 2-Iodoanilides bearing a branch
