862902-34-9Relevant academic research and scientific papers
Asymmetric addition of terminal alkynes to n-(Diphenylphosphinoyl)imines promoted by stoichiometric amounts of a proline-derlved ss-amino alcohol
Yan, Wenjin,Mao, Bin,Zhn, Shaoqun,Jiang, Xianxing,Liu, Zhongli,Wang, Rui
supporting information; experimental part, p. 3790 - 3794 (2009/12/07)
A new synthetic methodology for the preparation of optically active propargylamines is described. The alkynylation of aromatic, heteroaromatic, aliphatic and α,β-unsaturated N-(di-phenylphosphinoyl)imines was investigated by using dieth-ylzinc and a proline-derived β-amino alcohol, N-(Diphenylphosphinoyl)-protected propargylic amines can be synthesized in high yields and with good to excellent: enantio-selectivities.
Asymmetric ring opening of meso-epoxides with aromatic amines catalyzed by a new proline-based N,N′-dioxide-indium tris(triflate) complex
Gao, Bo,Wen, Yuehong,Yang, Zhigang,Huang, Xiao,Liu, Xiaohua,Feng, Xiaoming
experimental part, p. 385 - 390 (2009/04/08)
The catalytic asymmetric ring opening of meso-epoxides with aromatic amines was achieved using a new proline-based N,N′-dioxide-indium tris(triflate) complex in high yields (up to 99%) with excellent enantioselectivities (up to 99% ee) under mild conditio
Asymmetrie three-component strecker reactions catalyzed by trans-4-hydroxy-L-proline-derived N,N′-dioxides
Wen, Yuehong,Gao, Bo,Fu, Yingzi,Dong, Shunxi,Liu, Xiaohua,Feng, Xiaoming
experimental part, p. 6789 - 6795 (2009/07/11)
Novel trans-4-hydroxy-L-proline-derived N,N′-dioxides have been developed and used as efficient organocatalysts for the one-pot three-component Strecker reaction with an aldehyde, (1,1-diphenyl)methylamine, and TMSCN. Both aromatic and aliphatic aldehydes
Proline-based N-oxides as readily available and modular chiral catalysts. Enantioselective reactions of allyltrichlorosilane with aldehydes
Traverse, John F.,Zhao, Yu,Hoveyda, Amir H.,Snapper, Marc L.
, p. 3151 - 3154 (2007/10/03)
(Chemical Equation Presented) A proline-based N-oxide is identified that serves as an effective catalyst for the reaction of allyltrichlorosilane with aryl and α,β-unsaturated aldehydes at room temperature to afford the desired homoallylic alcohols in up to 92% ee. The chiral catalyst can be easily prepared from optically pure proline in three simple steps and 60% overall yield.
