862911-59-9Relevant articles and documents
SAR and biological evaluation of novel trans-3,4-dimethyl-4-arylpiperidine derivatives as opioid antagonists
Diaz, Nuria,Benvenga, Mark,Emmerson, Paul,Favors, Ryan,Mangold, Michael,McKinzie, Jamie,Patel, Nita,Peters, Steven,Quimby, Steven,Shannon, Harlan,Siegel, Miles,Statnick, Michael,Thomas, Elizabeth,Woodland, Joseph,Surface, Peggy,Mitch, Charles
, p. 3844 - 3848 (2007/10/03)
The phenolic hydroxy group of opiate-derived ligands is of known importance for biological activity. We have developed a SAR study around LY255582 by comparing the effect of the hydroxy group in the 2- and 4-position of the phenyl ring. Also, we have prov