863029-96-3

Upstream product

• 139-59-3 4-phenoxyanilin 
• 214470-72-1 4-chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile 
• 214470-61-8 7-(2-chloro-ethoxy)-6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carbonitrile 
• 214470-60-7 2-amino-4-(2-chloroethoxy)-5-methoxybenzoic acid methyl ester 
• 214470-56-1 4-(2-Chloro-ethoxy)-5-methoxy-benzoic acid methyl ester 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 214470-58-3 4-(2-chloroethoxy)-5-methoxy-2-nitrobenzoic acid methyl ester 

Downstream Products

• 863030-22-2 7-(2-[1,4']bipiperidinyl-1'-yl-ethoxy)-6-methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile 

Relevant academic research and scientific papers

3-Quinolinecarbonitrile protein kinase inhibitors

This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated wit

Synthesis and structure-activity relationships of 3-cyano-4(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors

A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells. (C) 2000 Elsevier Science Ltd.