7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile

Base Information

• Chemical Name: 7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile
• CAS No.: 863029-96-3
• Molecular Formula: C₂₅H₂₀ClN₃O₃
• Molecular Weight: 445.905
• Mol file: 863029-96-3.mol

Synonyms:7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile

Chemical Property of 7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile

There total 8 articles about 7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile (863029-96-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: K₂CO₃; (C₈H₁₇)3N(CH₃)Cl / acetone / Heating

2.1: HNO₃; AcOH / 50 °C

3.1: Fe; NH₄Cl / methanol / Heating

4.1: Heating

5.1: tetrahydrofuran / -78 °C

5.2: AcOH / 20 °C

6.1: POCl₃ / Heating

7.1: 2-ethoxy-ethanol / Heating

With (C₈H₁₇)3N(CH₃)Cl; nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; acetone;

DOI:10.1016/S0960-894X(00)00580-1

Reference yield:

4-(2-Chloro-ethoxy)-5-methoxy-benzoic acid methyl ester (214470-56-1) → 7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile (863029-96-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: HNO₃; AcOH / 50 °C

2.1: Fe; NH₄Cl / methanol / Heating

3.1: Heating

4.1: tetrahydrofuran / -78 °C

4.2: AcOH / 20 °C

5.1: POCl₃ / Heating

6.1: 2-ethoxy-ethanol / Heating

With nitric acid; iron; ammonium chloride; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; 2-ethoxy-ethanol;

DOI:10.1016/S0960-894X(00)00580-1

Reference yield:

2-amino-4-(2-chloroethoxy)-5-methoxybenzoic acid methyl ester (214470-60-7) → 7-(2-chloroethoxy)-6-methoxy-4-(4-phenoxyphenylamino)quinoline-3-carbonitrile (863029-96-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Heating

2.1: tetrahydrofuran / -78 °C

2.2: AcOH / 20 °C

3.1: POCl₃ / Heating

4.1: 2-ethoxy-ethanol / Heating

With trichlorophosphate; In tetrahydrofuran; 2-ethoxy-ethanol;

DOI:10.1016/S0960-894X(00)00580-1

upstream raw materials:

4-phenoxyanilin

4-chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile

4-hydroxy-3-methoxybenzoic acid methyl ester

4-(2-Chloro-ethoxy)-5-methoxy-benzoic acid methyl ester

Downstream raw materials:

7-(2-[1,4']bipiperidinyl-1'-yl-ethoxy)-6-methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile