863036-86-6Relevant academic research and scientific papers
A direct route to 2-alkyl-4-carbethoxy-5-vinyloxazoles
Zhang, Jianmin,Ciufolini, Marco A.
supporting information; experimental part, p. 4699 - 4701 (2010/09/20)
The reaction of an α-chloroglycinate ester with the dimethylaluminum acetylide derivative of phenyl propargyl ether provides the corresponding 5-vinyloxazole in 40-50% yield.
Development of an oxazole conjunctive reagent and application to the total synthesis of siphonazoles
Zhang, Jianmin,Polishchuk, Elena A.,Chen, Jie,Ciufolini, Marco A.
supporting information; experimental part, p. 9140 - 9151 (2010/03/01)
(Chemical Equation Presented) The preparation of 4-carbethoxy-5-methyl-2- (phenylsulfonyl)methyloxazole and its use in the elaboration of more complex oxazoles are described. A total synthesis of the unique natural products siphonazoles A and B, illustrates an application of this building block. A discussion of the biological activity of the siphonazoles is also presented.
Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative
Long, Kai,Boyce, Michael,Lin, He,Yuan, Junying,Ma, Dawei
, p. 3849 - 3852 (2007/10/03)
The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification.
