863132-17-6

Basic information

• Product Name: (3,4-dimethoxy-phenylethynyl)-trimethyl-silane
• Synonyms: (3,4-dimethoxy-phenylethynyl)-trimethyl-silane
• CAS NO: 863132-17-6
• Molecular Weight: 234.37
• Mol File: 863132-17-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (3,4-dimethoxy-phenylethynyl)-trimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-dimethoxy-phenylethynyl)-trimethyl-silane(863132-17-6)
• EPA Substance Registry System: (3,4-dimethoxy-phenylethynyl)-trimethyl-silane(863132-17-6)

Safety Data

• Hazardous Substances Data: 863132-17-6(Hazardous Substances Data)

Upstream product

• 1206482-93-0 4-(bromoethynyl)-1,2-dimethoxybenzene 
• 1066-54-2 trimethylsilylacetylene 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 91-16-7 1,2-dimethoxybenzene 
• 2859-78-1 4-Bromoveratrole 

Downstream Products

• 104967-55-7 2-[2-(3,4-dimethoxyphenyl)ethyl]-1-methyl-1,2,3,4-tetrahydroquinolineanol 
• 58335-56-1 1,4-bis(3,4-dimethoxyphenyl)buta-1,3-diyne 
• 85-63-2 (R)-laudanosine 
• 2688-77-9 (S)-laudanosine 
• 523-02-4 (S)-(-)-norcoralydine 
• 4747-98-2 S-(-)-Norlaudanosine 
• 50896-90-7 (-) N-norlaudanosine 
• 6872-27-1 (R)-(+)-xylopinine 
• 6957-27-3 3,4-dihydropapaverine 
• 863132-19-8 N-{2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethyl}-2,2,2-trifluoro-acetamide 
• 863132-09-6 2-[2-(3,4-dimethoxy-phenylethynyl)-4,5-dimethoxy-phenyl]-ethylamine 
• 4302-52-7 4-ethynylveratrole 

Relevant articles and documents

Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N -propargylanilines with diverse carbon pronucleophiles: Facile access to functionalized tetrahydroquinolines

Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with two types of carbon pronucleophiles (nitromethane as a sp3 carbon pronucleophile and phenylacetylenes as sp carbon pronucleophiles) proceeded to give the 2-substituted tetrahydroquinolines in good yields with 100percent atomic utilization without any additional external oxidants.

Cobalt(II)-based Metalloradical Activation of 2-(Diazomethyl)pyridines for Radical Transannulation and Cyclopropanation

A new catalytic method for the denitrogenative transannulation/cyclopropanation of in-situ-generated 2-(diazomethyl)pyridines is described using a cobalt-catalyzed radical-activation mechanism. The method takes advantage of the inherent properties of a CoIII-carbene radical intermediate and is the first report of denitrogenative transannulation/cyclopropanation by a radical-activation mechanism, which is supported by various control experiments. The synthetic benefits of the metalloradical approach are showcased with a short total synthesis of (±)-monomorine.

Enantioselective synthesis of (+)-(S)-laudanosine and (-)-(S)-xylopinine

The study presents a new pathway for the enantioselective synthesis of benzylisoquinoline alkaloids. The key steps of the synthesis of (+)-(S)-laudanosine (1) and (-)-(S)-xylopinine (2) are a Sonogashira coupling that builds up the C1-C8a bond of the benzylisoquinoline skeleton, an intramolecular Ti-catalyzed hydroamination of an alkyne, and a subsequent enantioselective imine reduction according to Noyori's protocol.