86319-72-4Relevant articles and documents
Synthesis of isoflavones by tandem demethylation and ring-opening/cyclization of methoxybenzoylbenzofurans
Kunyane, Phaladi,Sonopo, Molahlehi S.,Selepe, Mamoalosi A.
, p. 3074 - 3082 (2019/11/19)
The unexpected conversion of benzoylbenzofurans into isoflavones through an intramolecular cascade that involves deprotection and ring-opening/cyclization is described. This was discovered in an investigation of the possible transformation of benzoylbenzofurans into coumaronochromones. This route affords isoflavones in two major steps from acetophenones and benzoquinones. The transformation was validated by synthesizing differently substituted isoflavone derivatives and further applied to a concise synthesis of a potential anticancer lead compound, glaziovianin A (1).
Topical Nonsteroidal Antipsoriatic Agents. 2. 2,3-(Alkylidenedioxy)naphthalene Analogues of Lonapalene
Venuti, Michael C.,Loe, Brad E.,Jones, Gordon H.,Young, John M.
, p. 2132 - 2136 (2007/10/02)
A series of 2,3-(alkylidenedioxy)naphthalene analogues (5a-p) of lonapalene (RS-43179,1), a 5-lipoxygenase inhibitor currently under clinical investigation for the treatment of psoriasis, has been prepared and evaluated for topical inhibitory activity aga