115943-52-7Relevant articles and documents
Topical Nonsteroidal Antipsoriatic Agents. 2. 2,3-(Alkylidenedioxy)naphthalene Analogues of Lonapalene
Venuti, Michael C.,Loe, Brad E.,Jones, Gordon H.,Young, John M.
, p. 2132 - 2136 (1988)
A series of 2,3-(alkylidenedioxy)naphthalene analogues (5a-p) of lonapalene (RS-43179,1), a 5-lipoxygenase inhibitor currently under clinical investigation for the treatment of psoriasis, has been prepared and evaluated for topical inhibitory activity aga
Naphthalene anti-psoriatic agents
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, (2008/06/13)
Naphthalenes of the formula: STR1 wherein: m is 1 or 2; n is 1, 2, or 3; R1 is alkyl of one to seven carbon atoms or an optionally substituted phenyl; R2 is hydrogen, lower alkyl, lower alkoxy, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl, optionally substituted phenyl-lower-alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, hydroxy, or lower alkylthio are useful in relieving psoriasis.