863221-25-4

Usage

Molecular weight

475.96 g/mol

Physical state

White crystalline solid

Stereochemistry

(2S,4R)-

Derivative of

Pyrrolidinedicarboxylic acid and fluorene

Common use

Organic synthesis and pharmaceutical research

Potential applications

Development of drugs targeting neurological and psychiatric disorders

Upstream product

• 959130-62-2 (2S,4R)-4-(4-Chloro-benzyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 1039361-99-3 C₁₂H₁₄ClNO₃ 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

Properties and structure-activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I

The properties and structure-activity relationships (SAR) of a macrocyclic analogue of porcine protegrin I (PG-I) have been investigated. The lead compound, having the sequence cyclo-(-Leu-Arg-Leu-Lys-Lys-Arg-Arg-Trp-Lys-Tyr- Arg-Val-d-Pro-Pro-), shows an