863328-46-5Relevant academic research and scientific papers
Bicyclic nucleoside inhibitors of Varicella-Zoster virus: The effect of branching in the p-alkylphenyl side chain
Luoni, Giovanna,McGuigan, Christopher,Andrei, Graciela,Snoeck, Robert,De Clercq, Erik,Balzarini, Jan
, p. 3791 - 3796 (2005)
Further to the discovery of bicyclic furanopyrimidine nucleoside analogues (BCNAs) as potent anti-VZV agents, a branched series of this family of compounds was synthesised. The aim was to study the impact of the geometry and steric hindrance in the side c
The synthesis of [18F]fluoroarenes from the reaction of cyclotron-produced [18F]fluoride ion with diaryliodonium salts
Shah, Aneela,Pike, Victor W.,Widdowson, David A.
, p. 2043 - 2046 (2007/10/03)
Diaryliodonium salts have been shown to react with fluoride ion at 80°C in acetonitrile to generate aryl fluorides. The regioselectivity is controlled electronically and by the bulk of the ortho-substituents on the rings, with the latter the dominant factor such that electron-rich rings can be fluorinated. ortho-Substituted aryl fluorides can be selectively produced from unsymmetrical diaryliodonium salts. The process has been used to synthesise [18F] labelled aromatics by the use of cyclotron generated [18F]fluoride ion.
