86333-22-4Relevant academic research and scientific papers
Solvent-free synthesis of benzothiazolines in the presence of alumina
Kodomari, Mitsuo,Satoh, Akihito,Nakano, Ryo,Aoyama, Tadashi
, p. 3329 - 3335 (2008/02/13)
o-Aminothiophenol reacted with ketones and β-keto esters in the presence of alumina under mild and solvent-free conditions to afford the corresponding benzothiazolines in high yields. Alumina can be reused for subsequent reactions without any loss of the
Reaction between 2,2'-Dithiodianiline and Activated Alkynes. Synthesis of 4H-1,4-Benzothiazines
Liso, Gaetano,Trapani, Giuseppe,Reho, Antonia,Latrofa, Andrea,Loiodice, Fulvio
, p. 567 - 572 (2007/10/02)
By the title reaction acetylenic esters (2a-c), ketones (2d-g), and the nitrile (2h) gave in all cases the corresponding 4H-1,4-benzothiazines (3) together with other products whose nature depends on the alkyne used.Thus benzothiazoline and/or benzothiazole, benzothiazepine, and vinylsulphides were obtained in the representative cases (2c, f, h) studied in detail.Some of these latter compounds have been independently synthesised by reaction of 2-aminobenzenethiol with corresponding alkyne (2).In particular conditions by the reactions between 2,2'-dithiodianiline (1) and alkynes (2f, d) we isolated bisenamine compounds (19) and (20) respectively and their intermediacy in formation of the corresponding benzothiazines (3f) and (3d) was achieved.The mechanisms of the observed reactions are also suggested.
