86334-58-9Relevant academic research and scientific papers
Process Development for the Synthesis of a Monobactam Antibiotic-LYS228
Fei, Zhongbo,Wu, Quanbing,Gong, Wanben,Fu, Peng,Li, Cheng,Wang, Xianwen,Han, Yufeng,Li, Bin,Li, Lei,Wu, Bin,Zhao, Yi,Li, Jinjing,Zhu, Wenya,Qiu, Wenlong,Guo, Jing,Zhou, Jianguang,Li, Yuanqiang,Villa, Marco,Cheung, Chi Ming
, p. 363 - 370 (2020)
A scalable process for the novel monobactam antibiotic LYS228 has been developed. This paper covers a novel scalable process for producing β-lactam 10 in the multiple kilogram scale. An alternative approach to compound 7 without protecting-group exchange
MONOBACTAM ORGANIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
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, (2015/11/10)
This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
Antimicrobial 2-oxo-1-azetidinesulphonic acids
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, (2008/06/13)
Antimicrobial 2-oxo-1-azetidinesulphonic acids of the formula STR1 in which H2 N STR2 represents an amino-substituted thiazolyl group, R1 is lower alkyl which is substituted by carbamoyl, lower alkylsuphonyl, azido, piperidine-carbon
Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
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, (2008/06/13)
The manufacture of 1-sulpho-2-oxazetidine derivatives of the formula STR1 in which Het is an optionally amino-substituted, 5- or 6-membered, aromatic heterocycle containing 1 or 2 nitrogen atoms and optionally also an oxygen or sulphur atom, R1
