863434-29-1Relevant academic research and scientific papers
HIV INTEGRASE INHIBITORS
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, (2015/09/22)
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
Naphthyridinone (NTD) integrase inhibitors: N1 Protio and methyl combination substituent effects with C3 amide groups
Johns, Brian A.,Kawasuji, Takashi,Weatherhead, Jason G.,Boros, Eric E.,Thompson, James B.,Koble, Cecilia S.,Garvey, Edward P.,Foster, Scott A.,Jeffrey, Jerry L.,Fujiwara, Tamio
, p. 422 - 425 (2013/02/23)
Substituent effects of a series of N1 protio and methyl naphthyridinone HIV-1 integrase strand-transfer inhibitors has been explored. The effects of combinations of the N1 substituent and C3 amide groups was extensively studied to compare enzyme inhibitio
