863443-05-4

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-amino-5-[(4-fluorophenyl)methyl]pyridine-2-carboxylate serves as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, such as treating diseases or managing symptoms.
Used in Agrochemical Industry:
In the agrochemical sector, methyl 3-amino-5-[(4-fluorophenyl)methyl]pyridine-2-carboxylate acts as an intermediate in the production of pesticides, herbicides, or other crop protection agents. Its incorporation into these products can enhance their effectiveness in protecting crops from pests and diseases, thereby contributing to increased agricultural productivity.
Given the compound's role as an intermediate, its applications are primarily determined by the specific reactions and processes it undergoes during the synthesis of the final products in both the pharmaceutical and agrochemical industries.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 863443-03-2 2-bromo-5-[(4-fluorophenyl)methyl]-3-nitropyridine 
• 863443-02-1 5-[(4-fluorophenyl)methyl]-3-nitro-2(1H)-pyridinone 
• 863443-01-0 5-[(4-fluorophenyl)methyl]-2(1H)-pyridinone 
• 863443-00-9 (4-fluorophenyl)[6-(methyloxy)-3-pyridinyl]methanol 
• 1072448-08-8 3-amino-5-bromo-pyridine-2-carboxylic acid methyl ester 
• 863443-04-3 methyl 5-[(4-fluorophenyl)methyl]-3-nitro-2-pyridinecarboxylate 

Downstream Products

• 863437-68-7 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-N-[3-(1-pyrrolidinyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxamide 
• 863434-13-3 GSK₃₆₄₇₃₅ 
• 1417659-20-1 C₁₉H₁₉FN₂O₅ 
• 863434-76-8 C₁₉H₁₈FN₃O₄ 
• 1417659-21-2 C₂₀H₂₁FN₂O₅ 

Relevant academic research and scientific papers

HIV INTEGRASE INHIBITORS

The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

Palladium- and nickel-catalyzed cross-couplings of unsaturated halides bearing relatively acidic protons with organozinc reagents

(Chemical Equation Presented) A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups. A similar nickel-catalyzed reaction is described. The relative kinetic basicity of organozinc compounds as well as their stability toward acidic protons is also described.

A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2- pyridinecarboxylate

A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2- pyridinecarboxylate (1b), starting from 5-bromo-2-methoxypyridine (8) and 4-fluorobenzaldehyde (9), is described. Key steps in the process include lithium-bromine exchange of 8, addition of the

HIV INTEGRASE INHIBITORS

The present infention features compounds that are HIV integrase inhibitors and may be useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

HIV INTEGRASE INHIBITORS

The present infention features compounds that are HIV integrase inhibitors and may be useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.