863442-93-7

Upstream product

• 863442-92-6 ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate 
• 36239-09-5 ethyl chlorocarbonylacetate 

Downstream Products

• 863439-20-7 7-[(4-Fluorophenyl)methyl]-4-hydroxy-N-[(1R)-2-hydroxy-1-methylethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide 
• 863439-82-1 7-[(4-Fluorophenyl)methyl]-4-hydroxy-N-{2-[methyl(methylsulfonyl)amino]ethyl}-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide 
• 863432-40-0 7-[(4-fluorophenyl)methyl]-4-hydroxy-N-[2-(methoxy)ethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide 
• 863437-85-8 7-[(4-Fluorophenyl)methyl]-4-hydroxy-N-(2-hydroxy-1,1-dimethylethyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide 
• 1345734-07-7 C₂₄H₂₀FN₃O₄ 
• 1345734-06-6 C₂₄H₂₀FN₃O₄ 
• 1345734-02-2 C₂₃H₁₇F₂N₃O₃ 
• 1345734-10-2 C₂₄H₁₉F₂N₃O₃ 
• 1345734-09-9 C₂₅H₂₂FN₃O₅ 
• 1345734-08-8 C₂₄H₂₀FN₃O₄ 

Relevant academic research and scientific papers

HIV INTEGRASE INHIBITORS

The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1integrase inhibitors

A series of naphthyridinone HIV-1 integrase strand-transfer inhibitors have been designed based on a psdeudo-C2 symmetry element present in the two-metal chelation pharmacophore. A combination of two distinct inhibitor binding modes resulted in potent inhibition of the integrase strand-transfer reaction in the low nM range. Effects of aryl and N1 substitutions are disclosed including the impact on protein binding adjusted antiviral activity.

Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin- 2(1H)-one HIV integrase inhibitors

The medicinal chemistry and structure-activity relationships for a novel series of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV-integrase inhibitors are disclosed. Substituent effects were evaluated at the N-1, C-3, and 7-benzyl positions of the naph

HIV INTEGRASE INHIBITORS

The present infention features compounds that are HIV integrase inhibitors and may be useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.