863482-65-9

Upstream product

• 53334-59-1 (S)-1-phenylpropan-2-yl 4-methylbenzenesulfonate 
• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 122-78-1 phenylacetaldehyde 
• 103-79-7 1-phenyl-acetone 
• 608130-32-1 (R)-3-phenyl-2-(N-phenylaminooxy)propan-1-ol 
• 155498-78-5 Toluene-4-sulfonic acid (R)-2-hydroxy-3-phenyl-propyl ester 
• 17131-14-5 (R)-3-phenylpropane-1,2-diol 
• 104-53-0 3-phenyl-propionaldehyde 
• 1517-68-6 (S)-1-phenylpropan-2-ol 
• 61393-94-0 (R)-2-benzyloxirane 

Downstream Products

• 156-34-3 l-amphetamine 
• 167421-83-2 tert-butyl N-[(1R)-1-methyl-2-phenylethyl]carbamate 
• 33817-09-3 (R)-2-methylamino-1-phenylpropane 
• 2323-36-6 SELEGILINE 

Relevant academic research and scientific papers

Synthesis of (R)-selegiline via hydrolytic kinetic resolution

A short and enantioselective formal synthesis of (R)-selegiline has been achieved using Jacobsen's hydrolytic kinetic resolution (HKR) of phenyl propylene oxide.

An organo-catalytic approach to the enantioselective synthesis of (R)-selegiline

An efficient enantioselective synthesis of (R)-selegiline has been achieved by two routes, via proline-catalyzed α-aminooxylation as well as α-amination of phenylpropanaldehyde as the key step.

Asymmetric syntheses of both enantiomers of amphetamine hydrochloride via bakers' yeast reduction of phenylacetone

Both enantiomers of amphetamine hydrochloride were stereospecifically synthesised based on bakers' yeast reduction of phenylacetone. A simple and efficient method for the chiral inversion of (S)-1-phenyl-2-propanol 3 to (R)-1-phenyl-2-propanol 8 has been discussed.