863503-05-3Relevant academic research and scientific papers
Syntheses and biological activity of bisdaunorubicins
Zhang, Guisheng,Fang, Lanyan,Zhu, Lizhi,Sun, Duxin,Wang, Peng George
, p. 426 - 434 (2007/10/03)
To study the length and flexibility of the linkers between two monomers of bisdaunorubicins for their activity against cancer cells, seven bisdaunorubicins were rationally designed and synthesized through click chemistry. Their cytotoxicity was tested in
Syntheses and biological activities of disaccharide daunorubicins
Zhang, Guisheng,Fang, Lanyan,Zhu, Lizhi,Aimiuwu, Josephine E.,Shen, Jie,Cheng, Hao,Muller, Mark T.,Lee, Gun Eui,Sun, Duxin,Wang, Peng George
, p. 5269 - 5278 (2007/10/03)
Carbohydrate moiety is found in many anticancer nature products. To explore the carbohydrate moiety of daunorubicin in enhancing anticancer efficacy, several daunorubicin derivatives bearing disaccharide (1-8) have been synthesized. Their cytotoxicities w
A practical method for the stereoselective generation of β-2-deoxy glycosyl phosphates
Oberthuer, Markus,Leimkuhler, Catherine,Kahne, Daniel
, p. 2873 - 2876 (2007/10/03)
(Equation Presented) β-2-Deoxy sugar nucleotides are substrates used by a variety of glycosyltransferases (Gtfs). We have developed a chemical route to synthesize β-2-deoxy sugar phosphates that starts from α-glycosyl chlorides. Our approach reliably prov
