86352-16-1

Upstream product

• 100-52-7 benzaldehyde 
• 552-86-3 furoin 
• 98-01-1 furfural 
• 613-90-1 benzoyl cyanide 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 

Downstream Products

• 86358-28-3 1-(furan-2-yl)-2-phenyl-ethane-1,2-dione 
• 1591704-32-3 (S)-1-(furan-2-yl)-2-phenyl-2-oxoethyl butyrate 
• 1591704-38-9 C₁₆H₁₆O₄ 
• 1591704-34-5 (1R,2S)-1-(furan-2-yl)-2-phenylpent-4-ene-1,2-diol 
• 4949-09-1 2,5-di-furan-2-yl-3,6-diphenyl-pyrazine 

Relevant academic research and scientific papers

Preparation and properties of unsymmetrical benzoins and related compounds

Synthesis of unsymmetrical benzoins and their esters can be compromised by isomerisation via the enediol (or its anion). This could be avoided by suitable reaction conditions for the benzoins and their esters 2a/b and 3a/b but not for the 3-furyl compound 4a. A convenient synthesis of 3,5-dimethoxy- 2,4,6-trimetbylbenzaldehyde 10 is described and the compound was converted to the hindered benzoin 5a.

Reductive Coupling of Benzoyl Cyanide and Carbonyl Compounds by Aqueous Ti(III) Ions. A New Convenient and Selective Access to the Less Stable Mixed Benzoins

The reactive species formed by the Ti(III) ion reduction of benzoyl cyanide (1) adds to the C-atom of carbonyl compounds 2 under simple experimental conditions.The intermediate 1,2-diols 3 are smoothly converted, without isolation, into the less thermodynamically stable mixed benzoins 4, which are not accessible by the classical benzoin condensation.The possible mechanisms involved in the reaction are discussed.