86358-61-4Relevant academic research and scientific papers
Frustrated Lewis acid/Br?nsted base catalysts for direct enantioselective α-amination of carbonyl compounds
Shang, Ming,Wang, Xiaoxu,Koo, Seung Moh,Youn, Jennifer,Chan, Jessica Z.,Yao, Wenzhi,Hastings, Brian T.,Wasa, Masayuki
supporting information, p. 95 - 98 (2017/05/16)
A method for enantioselective direct α-amination reaction catalyzed by a sterically "frustrated" Lewis acid/Br?nsted base complex is disclosed. Cooperative functioning of the Lewis acid and Br?nsted base components gives rise to in situ enolate generation from monocarbonyl compounds. Subsequent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers α-aminocarbonyl compounds in high enantiomeric purity.
SYNTHESIS OF α-DIALKYLAMINOSTYRENES AND THEIR REACTION WITH AZODICARBOXYLIC ESTER AND COMPOUNDS CONTAINING AN ACTIVATED MULTIPLE BOND
Koikov, L. N.,Terent'ev, P. B.,Torochesnikov, V. N.,Kulikov, N. S.
, p. 110 - 118 (2007/10/02)
Lower α-dialkylaminostyrenes react with compounds containing an activated double bond by a mechanism of "vinyl" substitution with the formation of both disubstituted and monosubstituted compounds.The ester groups of the mono- and bisN,N'-di(methoxycarbon
