86358-97-6

Upstream product

• 75508-73-5 1-(2-methoxyphenyl)-3,3-dimethyl-2-butanone 
• 122271-14-1 E-2-(3,3-dimethyl-but-1-enyl)-phenol 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 529-28-2 4-iodoanisol 

Relevant academic research and scientific papers

Novel highly regioselective VO(acac)2/TBHP mediated oxidation of o-alkenyl phenols to o-hydroxybenzyl ketones

A novel mild methodology for the preparation of o-hydroxybenzyl ketones is described starting from o-alkenyl phenols and based on the VO(acac)2/TBHP (2 mol %/1.2 equiv) system. VO(acac)2 first catalyzes the epoxidation of o-alkenyl phenols and then the rearrangement of the epoxyphenols to ketones via the selective benzylic C-O cleavage and 1,2 hydride migration. The protocol has also been applied to set up a useful and easy one-pot conversion of o-alkenyl phenols to benzo[b]furans by means of the sequential addition of TFA, after the generation of the intermediate o-hydroxybenzyl ketones.

New Synthesis of Benzofurans by SRN1 Reaction of ortho-Iodoanisole

Starting from ortho-iodoanisole, 2-substituted benzofurans are obtained in high yield via aromatic nucleophilic radical substitution (SRN1).