86358-97-6

Basic information

• Product Name: 1-(2-hydroxyphenyl)-3,3-dimethylbutan-2-one
• Synonyms: 1-(2-hydroxyphenyl)-3,3-dimethylbutan-2-one
• CAS NO: 86358-97-6
• Molecular Weight: 192.258
• Mol File: 86358-97-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-hydroxyphenyl)-3,3-dimethylbutan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxyphenyl)-3,3-dimethylbutan-2-one(86358-97-6)
• EPA Substance Registry System: 1-(2-hydroxyphenyl)-3,3-dimethylbutan-2-one(86358-97-6)

Safety Data

• Hazardous Substances Data: 86358-97-6(Hazardous Substances Data)

Upstream product

• 529-28-2 4-iodoanisol 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 122271-14-1 E-2-(3,3-dimethyl-but-1-enyl)-phenol 
• 75508-73-5 1-(2-methoxyphenyl)-3,3-dimethyl-2-butanone 

Relevant articles and documents

Novel highly regioselective VO(acac)2/TBHP mediated oxidation of o-alkenyl phenols to o-hydroxybenzyl ketones

A novel mild methodology for the preparation of o-hydroxybenzyl ketones is described starting from o-alkenyl phenols and based on the VO(acac)2/TBHP (2 mol %/1.2 equiv) system. VO(acac)2 first catalyzes the epoxidation of o-alkenyl phenols and then the rearrangement of the epoxyphenols to ketones via the selective benzylic C-O cleavage and 1,2 hydride migration. The protocol has also been applied to set up a useful and easy one-pot conversion of o-alkenyl phenols to benzo[b]furans by means of the sequential addition of TFA, after the generation of the intermediate o-hydroxybenzyl ketones.