863600-81-1

Basic information

• Product Name: cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole
• Synonyms: cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole;endo-5-Amino-cis-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester
• CAS NO: 863600-81-1
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 224.2994
• Mol File: 863600-81-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole(863600-81-1)
• EPA Substance Registry System: cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole(863600-81-1)

Safety Data

• Hazardous Substances Data: 863600-81-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole is utilized as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure and reactivity allow for the creation of new drug candidates with potential therapeutic applications.
Used in Organic Chemistry:
In the field of organic chemistry, cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole serves as a building block for the assembly of more complex organic molecules. Its presence enables chemists to explore novel synthetic pathways and develop advanced materials with specific properties.
Used in Drug Development:
cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole is employed as a precursor in drug development, where its unique structure can be leveraged to create new pharmaceutical agents. Its potential applications in this area highlight its importance in the advancement of medicinal chemistry.
Used in Material Science:
cis-5-AMino-2-Boc-hexahydro-cyclopenta[c]pyrrole also finds use in material science, where its properties can be harnessed to develop new materials with specific characteristics. This can include the creation of novel polymers, coatings, or other materials with tailored properties for various applications.

Upstream product

• 863600-79-7 tert-butyl (cis-exo)-5-(benzylamino)-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate 
• 147528-20-9 N-(tert-butoxycarbonyl)-N-allyl-3-amino-1-propyne 
• 42268-68-8 allylpropargylamine 
• 146231-54-1 (3aR,6aS)-tert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 

Downstream Products

• 1217315-33-7 C₂₄H₃₅FN₂O₃ 
• 1217315-34-8 C₂₂H₃₄N₂O₃ 
• 1217315-35-9 C₂₄H₃₆N₂O₃ 
• 1280666-00-3 tert-butyl (cis-exo)-5-benzyloxycarbonylamino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate 
• 1280666-02-5 benzyl (cis-exo)-N-[1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-5-yl]carbamate 
• 1280666-04-7 benzyl (cis-exo)-N-[2-methyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]carbamate 
• 1416329-43-5 rac-cis-dihydrogen-2-boc-octahydro-cyclopcnta[c]pyrroic-5-ylamine 
• 1416329-44-6 (3aR,5S,6aS)-tert-butyl 5-(methylamino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 

Relevant articles and documents

DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.

DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.

Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc

The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 3-amino-8-azabicyclo[3.2.1]octane found in the CCR5 antagonist maraviroc.

An octahydro-cyclopenta[c]pyrrole series of inhibitors of the type 1 glycine transporter

We describe a novel series of inhibitors of the type 1 glycine transporter (GlyT1) as an approach to relieving the glutamatergic deficit that is thought to underlie schizophrenia. Synthesis and SAR follow-up of a series of octahydro-cyclopenta[c]pyrrole derivatives afforded potent in vitro inhibition of GlyT1 as well as in vivo activity in elevating CSF glycine. We also found that a 3-O(c-pentyl), 4-F substituent may serve as a surrogate for the widely used 3-trifluoromethoxy group, suggesting its application as an isostere for future medicinal chemistry studies.

Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity

The present application describes modulators of MCP-1 of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein X, Z, a, b, c, d, n, R1, R2, R3, R4, R5, R10, R