863643-77-0

Basic information

• Product Name: 4-(2-benzoyl-1-cyano-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-ylmethyl)nicotinic acid ethyl ester
• Synonyms: 4-(2-benzoyl-1-cyano-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-ylmethyl)nicotinic acid ethyl ester
• CAS NO: 863643-77-0
• Molecular Weight: 485.539
• Mol File: 863643-77-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-benzoyl-1-cyano-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-ylmethyl)nicotinic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-benzoyl-1-cyano-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-ylmethyl)nicotinic acid ethyl ester(863643-77-0)
• EPA Substance Registry System: 4-(2-benzoyl-1-cyano-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-ylmethyl)nicotinic acid ethyl ester(863643-77-0)

Safety Data

• Hazardous Substances Data: 863643-77-0(Hazardous Substances Data)

Upstream product

• 14301-36-1 N-[2-(3,4-dimethoxyphenyl)ethyl]formamide 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 10174-83-1 (±)-2-benzoyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile 

Relevant articles and documents

Protoberberines from Reissert- compounds. Part IX [1]. An alternative approach to dibenzoquinolizine- and isoquinonaphthyridin-13a-carboxylic acids, a novel synthesis of alangimarine

3,4-Dihydroisoquinoline-Reissert-compounds were alkylated to 1-benzyl- and 1-picolyl-derivatives, which in turn could selectively be hydrolized yielding various carboxylic acids, among others certain amino acids related to 3′,4′-deoxynorlaudanosoline carboxylic acid (DNLCA). These on treating with ethanolic KOH underwent cyclization to dibenzoquinolizine- and isoquinonaphthyridine-13a-carboxylic acids. Alternatively this cyclization also could be achieved by a more convenient one-pot procedure starting from the same dihydro-Reissert-compounds. Thermal decarboxylation afforded among others the alangia alkaloids alangimarine and dihydroalangimarine. Springer-Verlag 2004.