863676-75-9

Upstream product

• 863676-70-4 3-chloro-2-hydroxy-6-methylbenzoic acid ethyl ester 
• 77-78-1 dimethyl sulfate 
• 6555-40-4 ethyl 2-hydroxy-6-methylbenzoate 

Relevant academic research and scientific papers

Synthesis of chlorine-containing angucycline BE-23254 and its analogs

The total synthesis of BE-23254, an unusual angucycline antibiotic is reported. This is achieved by adopting a Hauser annulation and a DDQ-promoted aromatization as the key steps. The strategy has been generalized for the synthesis of several analogs of the target molecule. A regioselective preparation of chlorine-containing phenols is also described.

Total synthesis of BE-23254, a chlorinated angucycline antibiotic

The first synthesis of BE-23254, an unusual angucycline antibiotic, is reported. It involves regioselective condensation of naphthalenone 4 and chlorine-containing isobenzofuranone 16 as the key step.