863676-70-4

Upstream product

• 3419-32-7 ethyl 5-methyl-3-oxocyclohexene-4-carboxylate 
• 4652-27-1 4-methoxy-3-buten-2-one 
• 1031694-93-5 4-chloro-1-ethoxy-1,3-bis-(trimethylsilyloxy)buta-1,3-diene 
• 6555-40-4 ethyl 2-hydroxy-6-methylbenzoate 

Downstream Products

• 863676-76-0 ethyl 3-chloro-2-methoxy-6-dibromomethylbenzoate 
• 863676-75-9 ethyl 3-chloro-2-methoxy-6-methylbenzoate 

Relevant academic research and scientific papers

Synthesis of functionalized salicylates by formal [3+3] cyclocondensation of 1,3-bis(silyloxy)buta-1,3-dienes with 3-alkoxy-2-en-1-ones

The formal [3+3] cyclization of 1,3-bis(silyloxy)buta-1,3-dienes with 1-aryl-3-ethoxyprop-2-en-1-ones, available by Heck reaction of benzoyl chlorides with ethyl vinyl ether, afforded a variety of 6-arylsalicylates. The reaction of the products with conce

Synthesis of chlorine-containing angucycline BE-23254 and its analogs

The total synthesis of BE-23254, an unusual angucycline antibiotic is reported. This is achieved by adopting a Hauser annulation and a DDQ-promoted aromatization as the key steps. The strategy has been generalized for the synthesis of several analogs of the target molecule. A regioselective preparation of chlorine-containing phenols is also described.

Total synthesis of BE-23254, a chlorinated angucycline antibiotic

The first synthesis of BE-23254, an unusual angucycline antibiotic, is reported. It involves regioselective condensation of naphthalenone 4 and chlorine-containing isobenzofuranone 16 as the key step.