197376-41-3

Usage

Uses

Used in Organic Synthesis:
(3-Bromo-pyridin-2-yl)-acetic acid ethyl ester is used as a building block in organic synthesis for the creation of various chemical compounds. Its unique structure and functional groups make it a versatile component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (3-Bromo-pyridin-2-yl)-acetic acid ethyl ester is used as a key intermediate in the development of new drugs. Its potential applications in the synthesis of pharmaceuticals include the creation of novel therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Development:
(3-Bromo-pyridin-2-yl)-acetic acid ethyl ester is also utilized in the development of agrochemicals, such as pesticides and herbicides. Its unique chemical properties allow for the design of new agrochemicals with enhanced performance and selectivity, contributing to more effective and sustainable agricultural practices.
Safety and Handling:
As a pyridine derivative, (3-Bromo-pyridin-2-yl)-acetic acid ethyl ester must be handled and stored according to proper safety protocols to ensure the safety of researchers and the environment. This includes the use of appropriate personal protective equipment, handling in well-ventilated areas, and proper disposal of waste materials.

Upstream product

• 38749-79-0 3-bromo-2-picoline 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 55899-29-1 ethyl 4-bromopyrazolo[1,5-a]pyridine-3-carboxylate 
• 86369-48-4 ethyl 2-(3-cyanopyridin-2-yl)acetate 
• 1214911-59-7 C₁₂H₁₅NO₂ 

Relevant academic research and scientific papers

PYRIDAZINONES AND METHODS OF USE THEREOF

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

Synthesis of Tetrahydronaphthyridines from Aldehydes and HARP Reagents via Radical Pictet-Spengler Reactions

The combination of aldehydes with newly designed HARP (halogen amine radical protocol) reagents gives access to α-substituted tetrahydronaphthyridines. By using different HARP reagents, various regioisomeric structures can be prepared in a single operation. These products, which are of high value in medicinal chemistry, are formed in a predictable manner via a formal Pictet-Spengler reaction of electron-poor pyridines that would not participate in the corresponding polar reactions.

1 -AMINO-TRIAZOLO(1,5-A)PYRIDINE-SUBSTITUTED UREA DERIVATIVE AND USES THEREOF

Provided herein is a compound, 1-(4-(3-amino-[1,2,3]triazolo[1,5-a]pyridin-4-yl)phenyl)- 3-(3-chlorophenyl)urea, pharmaceutical compositions thereof, and crystal forms thereof. Also provided are particles (e.g., nanoparticles) comprising the compound, and pharmaceutical compositions thereof, that are mucus penetrating. Also provided herein are methods and kits for using the compound, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

UREA DERIVATIVES AND USES THEREOF

The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

The synthesis of thienopyridines from ortho-halogenated pyridine derivatives; Part 2

Synthetic routes to the ortho-halogenated pyridine derivatives, ethyl 2- and 4-chloro-3-pyridylacetate, ethyl 3-bromo-4-pyridylacetate and ethyl 3-bromo-2-pyridylacetate, which have methylene groups activated by the ester functionality are reported. Reaction of these pyridines with carbon disulfide in the presence of sodium hydride, followed by quenching with iodomethane, results in the formation of the corresponding thienopyridines in moderate yields.