863717-91-3Relevant academic research and scientific papers
Preparation of carbocycles via base-catalyzed endo-mode cyclization of allenes
Mukai, Chisato,Kuroda, Norikazu,Ukon, Rie,Itoh, Rumiko
, p. 6282 - 6290 (2007/10/03)
A new and reliable procedure for constructing five- to seven-membered carbocycles via an endomode ring-closing reaction of 1-phenylsulfonylallenes with a substituent that has a terminal active methine moiety at the C 1-position has been developed. Trisubstituted 1-phenylsulfonylallenes underwent a similar endo-mode ring-closing reaction to produce the corresponding five- to seven-membered carbocycles, while the formation of six- and seven-membered carbocycles from the corresponding tetrasubstituted allene was not realized. In addition, the introduction of an aromatic ring to the alkyl side chain of the starting allenes made possible the construction not only of normal-sized carbocycles but also an eight-membered framework.
