863779-22-0

Upstream product

• 866993-80-8 3-phenyl-3-p-tolyloxy-1,3-dihydroindol-2-one 
• 99-89-8 4-Isopropylphenol 
• 139018-14-7 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one 
• 42773-27-3 3-chloro-3-phenyl-1,3-dihydroindol-2-one 
• 106-44-5 p-cresol 

Downstream Products

• 912296-51-6 3-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-dihydroindole-2-thione 

Relevant academic research and scientific papers

Catalytic Enantioselective 1,3-Alkyl Shift in Alkyl Aryl Ethers: Efficient Synthesis of Optically Active 3,3′-Diaryloxindoles

Reported is the first organocatalytic asymmetric 1,3-alkyl shift in alkyl aryl ethers for the synthesis of chiral 3,3′-diaryloxindoles using a chiral Br?nsted acid catalyst. Preliminary results showed that each enantiomer of the 3,3′-diaryloxindole, and a

Friedel-Crafts alkylations of electron-rich aromatics with 3-hydroxy-2-oxindoles: Scope and limitations

A Lewis acid-catalyzed nucleophilic addition of electron rich aromatics with 3-hydroxy-2-oxindoles 5 was developed. The reaction is believed to proceed through the 2H-indol-2-one ring system 9, which eventually reacts with various electron-rich aromatics to afford a variety of 2-oxindoles with an all-carbon quaternary center at the pseudobenzylic position (4, 8, 13, and 16) in high yields. The methodology provides an expeditious route to the tetracyclic core (3) of diazonamide (1), and azonazine (2) as well as the tricyclic core of asperazine (6a), idiospermuline (6b), and calycosidine (6c) viz. C(3a)-arylpyrroloindolines 7 having an all-carbon quaternary center on further synthetic elaboration.

3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION

Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.

A mild thermal and acid-catalyzed rearrangement of O-aryl ethers into ortho-hydroxy arenes

(Chemical Equation Presented) An unusual rearrangement of an O-aryl ether to an ortho-hydroxyaryl system was discovered during our studies on the synthesis of diazonamide A. We discuss the exploration of this rearrangement under mild thermal and both Bron