863781-34-4Relevant academic research and scientific papers
Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines
Otrubova, Katerina,Lushington, Gerald,Vander Velde, David,McGuire, Kathleen L.,McAlpine, Shelli R.
, p. 530 - 544 (2008/09/18)
We report an extensive structure-activity relationship (SAR) of 62 compounds active against two drug-resistant colon cancer cell lines. Our comprehensive evaluation of two generations of compounds utilizes SAR, NMR, and molecular modeling to evaluate the
MACROCYCLIC PEPTIDES AND METHODS FOR MAKING AND USING THEM
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Page/Page column 42, (2008/06/13)
The invention provides novel macrocyclic peptides and methods for their preparation. The invention also provides pharmaceutical compositions and methods to treat, prevent or ameliorate a cell proliferative disease or conditions, e.g., a cancer, in a subje
High-yielding macrocyclization conditions used in the synthesis of novel Sansalvamide A derivatives
Styers, Thomas J.,Rodriguez, Rodrigo,Pan, Po-Shen,McAlpine, Shelli R.
, p. 515 - 517 (2007/10/03)
Described are the syntheses of nine Sansalvamide A derivatives using new, high-yielding, in situ deprotection-cyclization conditions that are general for this series of macrocycles, 55% average for both steps. This is 10-fold greater than previously repor
Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29
Styers, Thomas J.,Kekec, Ahmet,Rodriguez, Rodrigo,Brown, Joseph D.,Cajica, Julia,Pan, Po-Shen,Parry, Emily,Carroll, Chris L.,Medina, Irene,Corral, Ricardo,Lapera, Stephanie,Otrubova, Katerina,Pan, Chung-Mao,McGuire, Kathleen L.,McAlpine, Shelli R.
, p. 5625 - 5631 (2007/10/03)
We report the synthesis of thirty-six Sansalvamide A derivatives, and their biological activity against colon cancer HT-29 cell line, a microsatellite stable (MSS) colon cancer cell-line. The thirty-six compounds can be divided into three subsets, where t
Synthesis and cytotoxicity of novel Sansalvamide A derivatives
Carroll, Chris L.,Johnston, Jennifer V. C.,Kekec, Ahmet,Brown, Joseph D.,Parry, Emily,Cajica, Julia,Medina, Irene,Cook, Kristina M.,Corral, Ricardo,Pan, Po-Shen,McAlpine, Shelli R.
, p. 3481 - 3484 (2007/10/03)
(Chemical Equation Presented) Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combi
