863781-46-8Relevant articles and documents
Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines
Otrubova, Katerina,Lushington, Gerald,Vander Velde, David,McGuire, Kathleen L.,McAlpine, Shelli R.
, p. 530 - 544 (2008/09/18)
We report an extensive structure-activity relationship (SAR) of 62 compounds active against two drug-resistant colon cancer cell lines. Our comprehensive evaluation of two generations of compounds utilizes SAR, NMR, and molecular modeling to evaluate the
Synthesis and cytotoxicity of novel Sansalvamide A derivatives
Carroll, Chris L.,Johnston, Jennifer V. C.,Kekec, Ahmet,Brown, Joseph D.,Parry, Emily,Cajica, Julia,Medina, Irene,Cook, Kristina M.,Corral, Ricardo,Pan, Po-Shen,McAlpine, Shelli R.
, p. 3481 - 3484 (2007/10/03)
(Chemical Equation Presented) Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combi