863781-50-4Relevant academic research and scientific papers
A comprehensive study of Sansalvamide A derivatives: The structure-activity relationships of 78 derivatives in two pancreatic cancer cell lines
Pan, Po-Shen,Vasko, Robert C.,Lapera, Stephanie A.,Johnson, Victoria A.,Sellers, Robert P.,Lin, Chun-Chieh,Pan, Chung-Mao,Davis, Melinda R.,Ardi, Veronica C.,McAlpine, Shelli R.
experimental part, p. 5806 - 5825 (2009/12/24)
We report an extensive structure-activity relationship (SAR) of 78 compounds active against two pancreatic cancer cell lines. Our comprehensive evaluation of these compounds utilizes SAR that allow us to evaluate which features of potent compounds play a
Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines
Otrubova, Katerina,Lushington, Gerald,Vander Velde, David,McGuire, Kathleen L.,McAlpine, Shelli R.
, p. 530 - 544 (2008/09/18)
We report an extensive structure-activity relationship (SAR) of 62 compounds active against two drug-resistant colon cancer cell lines. Our comprehensive evaluation of two generations of compounds utilizes SAR, NMR, and molecular modeling to evaluate the
Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29
Styers, Thomas J.,Kekec, Ahmet,Rodriguez, Rodrigo,Brown, Joseph D.,Cajica, Julia,Pan, Po-Shen,Parry, Emily,Carroll, Chris L.,Medina, Irene,Corral, Ricardo,Lapera, Stephanie,Otrubova, Katerina,Pan, Chung-Mao,McGuire, Kathleen L.,McAlpine, Shelli R.
, p. 5625 - 5631 (2007/10/03)
We report the synthesis of thirty-six Sansalvamide A derivatives, and their biological activity against colon cancer HT-29 cell line, a microsatellite stable (MSS) colon cancer cell-line. The thirty-six compounds can be divided into three subsets, where t
Synthesis and cytotoxicity of novel Sansalvamide A derivatives
Carroll, Chris L.,Johnston, Jennifer V. C.,Kekec, Ahmet,Brown, Joseph D.,Parry, Emily,Cajica, Julia,Medina, Irene,Cook, Kristina M.,Corral, Ricardo,Pan, Po-Shen,McAlpine, Shelli R.
, p. 3481 - 3484 (2007/10/03)
(Chemical Equation Presented) Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combi
