863868-29-5

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 73183-34-3 bis(pinacol)diborane 
• 79630-23-2 3-bromo-4-fluorobenzonitrile 

Relevant academic research and scientific papers

ORGANIC MOLECULES FOR OPTOELECTRONIC DEVICES

The invention relates to an organic molecule for the use in optoelectronic devices. According to the invention, the organic compound has - a first chemical moiety with a structure of formula (I) and - three second chemical moieties, each independently fro

Designing dual emitting cores for highly efficient thermally activated delayed fluorescent emitters

Improving the efficiency and the stability of TADF-based OLED devices is of vital importance for OLED applications. In this work, two dual emitting cores (2,2′-DPXZ-PN and 3,3′-DPXZ-PN) were rationally synthesized by connecting two identical TADF emitting

Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.

CONDENSED CYCLIC COMPOUND, COMPOSITION INCLUDING THE SAME, AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE CONDENSED CYCLIC COMPOUND

A condensed cyclic compound represented by Formula 1: wherein in Formula 1 groups and variables are the same as described in the specification.

Iridium complexes of N-heterocyclic carbenes in C-H borylation using energy efficient microwave technology: Influence of structure, ligand donor strength and counter ion on catalytic activity

Bridged and unbridged N-heterocyclic carbene (NHC) ligands were metalated with [Ir(COD)Cl]2 to give iridium(i) mono- and biscarbene substituted catalysts [Ir(COD)NHC(Cl)] and [Ir(COD)(NHC)2][X] (X: I, PF 6, BF4, CF3COO, OTf). The prepared NHC-complexes were tested in the C-H borylation reaction of aromatic carbons with bis(pinacolato)diboron (B2pin2) and pinacolborane (HBpin). The use of microwave technology in this study not only facilitates a time efficient screening of a wide range of influences such as ligand σ-donor strength and structural motif as well as the effects of the complex counter ion, but also provides an energy efficient heating source. Catalyst 6TFA, which features a chelating NHC ligand, proved to be most effective catalyst and further investigations with this complex in the borylation of mono- and disubstituted benzene derivatives exploring chemo- and regioselectivity were undertaken. The Royal Society of Chemistry 2009.

Process for producing cyano substituted arene boranes and compounds

A process for producing cyano substituted arene boranes is described. The compounds are useful intermediates to pharmaceutical compounds using the cyano group as a reactant.

Sterically directed functionalization of aromatic C-H bonds: Selective borylation ortho to cyano groups in arenes and heterocycles

Ir-catalyzed borylations of 4-substituted benzonitriles are described. In contrast to electrophilic aromatic substitutions and directed ortho metalations, C-H activation/borylation enables functionalization at the 2-position, adjacent to the cyano group, when the 4-subsitutent is larger than cyano. When an excess of borane reagent is used, diborylation can be achieved with a single regioisomer being formed in certain cases. Extension of sterically directed borylation to cyano-substituted, five- and six-membered ring heterocycles is also reported.