863869-79-8Relevant academic research and scientific papers
Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates
Gangjee, Aleem,Zeng, Yibin,McGuire, John J.,Kisliuk, Roy L.
, p. 5329 - 5336 (2007/10/03)
We report, for the first time, the biological activities of four-carbon-atom bridged classical antifolates on dihydrofolate reductase (DHFR), thymidylate synthase (TS), and folylpoly-glutamate synthetase (FPGS) as well as antitumor activity. Extension of
