863767-87-7

Upstream product

• 17857-14-6 (3-carboxypropyl)(triphenyl)phosphonium bromide 
• 863767-86-6 (4E/Z)-5-[4-(methoxycarbonyl)phenyl]pent-4-enoic acid 

Downstream Products

• 863767-95-7 diethyl N-{4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamate 
• 863767-94-6 diethyl N-{4-[4-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)butyl]benzoyl}-L-glutamate 
• 863869-79-8 4-[4-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)butyl]benzoic acid 
• 863767-93-5 4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoic acid 
• 863767-91-3 methyl 4-[4-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoate 
• 863767-90-2 methyl 4-[4-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)butyl]benzoate 
• 863767-88-8 chloromethyl (4'-carbomethoxyphenyl)butyl ketone 
• 1026793-20-3 4-(4-chlorocarbonyl-butyl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity

6-Substituted classical pyrrolo[2,3-d]pyrimidine antifolates with a three- to six-carbon bridge between the heterocycle and the benzoyl-L-glutamate (compounds 2-5, respectively) were synthesized starting from methyl 4-formylbenzoate and a Wittig reaction

Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates

We report, for the first time, the biological activities of four-carbon-atom bridged classical antifolates on dihydrofolate reductase (DHFR), thymidylate synthase (TS), and folylpoly-glutamate synthetase (FPGS) as well as antitumor activity. Extension of